Effects of a SARS-associated coronavirus vaccine in monkeys
Identifieur interne : 006405 ( Main/Exploration ); précédent : 006404; suivant : 006406Effects of a SARS-associated coronavirus vaccine in monkeys
Auteurs : WENTAO GAO [États-Unis] ; Azaibi Tamin [États-Unis] ; Adam Soloff [États-Unis] ; Leonardo D'Aiuto [États-Unis] ; Edward Nwanegbo [États-Unis] ; Paul D. Robbins [États-Unis] ; William J. Bellini [États-Unis] ; Simon Barratt-Boyes [États-Unis] ; Andrea Gambotto [États-Unis]Source :
- Lancet : (British edition) [ 0140-6736 ] ; 2003.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Vaccination, Singe.
English descriptors
- KwdEn :
Abstract
The causative agent of severe acute respiratory syndrome (SARS) has been identified as a new type of coronavirus. Here, we have investigated the ability of adenoviral delivery of codon-optimised SARS-CoV strain Urbanl structural antigens spike protein S1 fragment, membrane protein, and nucleocapsid protein to induce virus-specific broad Immunity In rhesus macaques. We Immunised rhesus macaques Intramuscularly with a combination of the three Ad5-SARS-CoV vectors or a control vector and gave a booster vaccination on day 28. The vaccinated animals all had antibody responses against spike protein S1 fragment and T-cell responses against the nucleocapsid protein. All vaccinated animals showed strong neutralising antibody responses to SARS-CoV Infection In vitro. These results show that an adenoviral-based vaccine can Induce strong SARS-Cov-specific immune responses in the monkey, and hold promise for development of a protective vaccine against the SARS causal agent.
Affiliations:
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Here, we have investigated the ability of adenoviral delivery of codon-optimised SARS-CoV strain Urbanl structural antigens spike protein S1 fragment, membrane protein, and nucleocapsid protein to induce virus-specific broad Immunity In rhesus macaques. We Immunised rhesus macaques Intramuscularly with a combination of the three Ad5-SARS-CoV vectors or a control vector and gave a booster vaccination on day 28. The vaccinated animals all had antibody responses against spike protein S1 fragment and T-cell responses against the nucleocapsid protein. All vaccinated animals showed strong neutralising antibody responses to SARS-CoV Infection In vitro. These results show that an adenoviral-based vaccine can Induce strong SARS-Cov-specific immune responses in the monkey, and hold promise for development of a protective vaccine against the SARS causal agent.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li><li>Pennsylvanie</li></region><settlement><li>Pittsburgh</li></settlement><orgName><li>Université de Pittsburgh</li></orgName></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Wentao Gao" sort="Wentao Gao" uniqKey="Wentao Gao" last="Wentao Gao">WENTAO GAO</name></region><name sortKey="Barratt Boyes, Simon" sort="Barratt Boyes, Simon" uniqKey="Barratt Boyes S" first="Simon" last="Barratt-Boyes">Simon Barratt-Boyes</name><name sortKey="Bellini, William J" sort="Bellini, William J" uniqKey="Bellini W" first="William J." last="Bellini">William J. Bellini</name><name sortKey="D Aiuto, Leonardo" sort="D Aiuto, Leonardo" uniqKey="D Aiuto L" first="Leonardo" last="D'Aiuto">Leonardo D'Aiuto</name><name sortKey="Gambotto, Andrea" sort="Gambotto, Andrea" uniqKey="Gambotto A" first="Andrea" last="Gambotto">Andrea Gambotto</name><name sortKey="Gambotto, Andrea" sort="Gambotto, Andrea" uniqKey="Gambotto A" first="Andrea" last="Gambotto">Andrea Gambotto</name><name sortKey="Gambotto, Andrea" sort="Gambotto, Andrea" uniqKey="Gambotto A" first="Andrea" last="Gambotto">Andrea Gambotto</name><name sortKey="Nwanegbo, Edward" sort="Nwanegbo, Edward" uniqKey="Nwanegbo E" first="Edward" last="Nwanegbo">Edward Nwanegbo</name><name sortKey="Robbins, Paul D" sort="Robbins, Paul D" uniqKey="Robbins P" first="Paul D." last="Robbins">Paul D. Robbins</name><name sortKey="Soloff, Adam" sort="Soloff, Adam" uniqKey="Soloff A" first="Adam" last="Soloff">Adam Soloff</name><name sortKey="Tamin, Azaibi" sort="Tamin, Azaibi" uniqKey="Tamin A" first="Azaibi" last="Tamin">Azaibi Tamin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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